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Skeletal Muscle Differentiation

Genea Biocells developed the world’s first protocol to differentiate pluripotent stem cells to skeletal muscle with high yields and without cell sorting or genetic manipulation. Myotubes are contractile, express typical muscle markers and show striated sarcomeres.

Muscle is generated from human pluripotent stem cells in 3 steps, via satellite-like or progenitor cells and myoblasts that then fuse to multinucleated myotubes in the third step. The process yields almost pure populations of myogenic cells and is highly efficient.

Generation of Skeletal Muscle